Scientist/Engineer – Purification Process Development

Location: Lebanon, NH

Department: Affinity Purification Development

Type: Full Time

Min. Experience: Experienced

About Avitide

Avitide provides a platform technology to rapidly discover and develop high-performance affinity purification solutions for the biopharmaceutical development and manufacturing industry.  Avitide is seeking a qualified candidate to build upon their motivated and highly integrated, interdisciplinary team to pursue the rapid development of novel affinity separation solutions for our biopharmaceutical partners. The Avitide technology enables its partners with exclusive, high-yield, high purity affinity separation technologies that are delivered with an industry-leading service timeline to reduce cost of manufacturing and accelerate the delivery of new medicines to patients. 

Avitide's founding team brings substantial expertise and a track record of success in commercializing innovative biopharmaceutical discovery and manufacturing platform technologies.  Avitide is financed by top-tier venture capital firms such as Polaris Venture Partners, OrbiMed Advisors, SV Life Sciences, NeoMed Management, Mithril Capital Management and Borealis Ventures.

Avitide moved into a modern 30 000 square foot facility during 2016 that is located in New Hampshire’s beautiful Upper Connecticut River Valley, and is minutes from Dartmouth College, the Geisel School of Medicine, the Thayer School of Engineering, the Tuck School of Business, and Dartmouth-Hitchcock Medical Center.  The surrounding New Hampshire and Vermont areas are renowned for its premier skiing, hiking, kayaking, and biking.  Avitide offers compensation packages comprised of competitive salary, bonus, benefits, and equity components and career growth solely based upon merit.

About This Position

A successful candidate will join Avitide to lead affinity resin development programs conducted for our commercial partners.  Key responsibilities will leverage your current experience of process development for the optimization, scouting, and delivery of novel affinity separation matrices. Ultimately this leads to interfacing with biopharmaceutical companies to facilitate adoption of the technology. Avitide seeks candidates who are highly self-motivated and can work in a collaborative fashion with other interdisciplinary team members in a fast-paced company that seeks to transform downstream bioprocessing.

Qualifications and Experience:

  • Degree (BS/MS/PhD) in biological sciences, biochemistry, or biochemical/chemical engineering
  • Industrial experience within a biopharmaceutical bioprocess development setting
  • Expertise in development of protein and biologics purification processes
  • Expertise in automated/high-throughput chromatographic screening using DOE methodologies
  • Knowledge of biopharmaceutical purification scale-up/scale-down principles
  • Experience with protein quality control or release assays
  • Demonstrated history of strong hands-on ability, problem solving, and independent experimental design and execution
  • Demonstrated aptitude in managing multiple parallel projects
  • Timely and very strong communication skills

Duties and Responsibilities:

  • Actively contribute to the design, development, optimization, and delivery of novel Avitide affinity resins to Avitide’s biopharmaceutical development and manufacturing partners
  • Collaborate with downstream bioprocessing engineers at partner companies to streamline technology transfer and integration of Avitide Affinity Resins into partner processes
  • Preparation of data and presentations for external partner review
  • High throughput chromatographic screening using DOE and QbD principles
  • Purification process development using affinity capture and polish resins, and membranes
  • CIP validation and evaluation of protein and column stability
  • Work closely with the Affinity Ligand Discovery and High-Throughput Production teams to rapidly translate affinity purification leads to affinity resins for partner evaluations

Desirable Skills:

  • Experience in biopharmaceutical analytical method development and execution (product purity impurity analysis, product release assays, stability assays)
  • Experience with BioSolve or another bioprocess cost modeling software

Avitide Cultural Qualities

  • Demonstrate creativity and innovation
  • Actively contribute to our collaborative team culture
  • Ability to work autonomously and effectively under broad directives
  • Agile and quick to adapt
  • Excellent and timely communication skills
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