Senior Scientist/Principal Scientist – HDX Mass Spectrometry

Location: Lebanon, NH

Department: Bioanalytics and Purification Development

Type: Full Time

Min. Experience: Experienced

About Avitide

Avitide is a biotechnology company that provides a platform technology to rapidly discover and deliver high-performance affinity purification solutions for the biopharmaceutical development and manufacturing industry.  Avitide is seeking a qualified candidate to build upon their motivated and highly integrated, interdisciplinary team to pursue the rapid development of novel affinity separation solutions for our biopharmaceutical partners. The Avitide technology enables its partners with exclusive, high-yield, high purity affinity separation technologies that are delivered with an industry-leading service timeline to reduce cost of manufacturing and accelerate the delivery of new medicines to patients. 

Avitide's founding team brings substantial expertise and a track record of success in commercializing innovative biopharmaceutical discovery and manufacturing platform technologies.  Avitide is financed by top-tier private equity and venture capital firms such as Mithril Capital Management, Polaris Venture Partners, OrbiMed Advisors, SV Life Sciences, NeoMed Management, and Borealis Ventures.

Avitide is located in New Hampshire’s beautiful Upper Connecticut River Valley, and is minutes from Dartmouth College, the Geisel School of Medicine, the Thayer School of Engineering, the Tuck School of Business, and Dartmouth-Hitchcock Medical Center.  The surrounding New Hampshire and Vermont areas are renowned for its premier skiing, hiking, kayaking, and biking.  Avitide offers individually tailored compensation packages comprised of competitive salary, bonus, benefits, and equity components.

About This Position

The successful candidate will build an HDX-MS laboratory and expertise within Avitide. The role demands a subject matter expert to take a scientific leadership role to both discover and demonstrate means by which HDX-MS can be applied to improve our ligands and affinity resins. Avitide seeks candidates who are highly self-motivated and can work in a collaborative fashion with other interdisciplinary team members in a fast-paced company that seeks to transform the downstream bioprocessing industry.

Qualifications and Experience

  • Principal expertise in HDX-MS analysis of biologics and biological interactions
  • Experience with associated techniques
    • Peptide mapping
    • MS/MS sequencing of peptides
    • MS based degradation studies of proteins and peptides
  • PhD/MS preferably with 1+ years of industrial experience within a biopharmaceutical research and development setting
  • Strong organizational and time management skills to coordinate demands from multiple projects
  • Demonstrated history of strong hands-on ability, problem solving, and independent experimental design and execution

Duties and Responsibilities

  • Establish HDX technology and capability within Avitide
  • Provide scientific leadership and domain expertise in the field of mass spectrometry within Avitide
  • Actively seek and develop MS technologies to help improve Avitide product development

Desirable Skills

  • High throughput data analysis and automation of data analysis (“scripting”)
  • Experience with Waters Q-ToF and Acquity UPLC systems and software

Avitide Cultural Qualities

  • Demonstrate creativity and innovation
  • Actively contribute to our collaborative team culture
  • Ability to work autonomously and effectively under broad directives
  • Agile and quick to adapt
  • Excellent and timely communication skills


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